1

Walmart

Image: Marques Thomas

When it comes to big brands, Walmart is one of the largest in the country, and even the world. But its humble beginnings can be traced back to Bentonville, Arkansas , where Sam Walton opened his first store, aptly named Walton’s, in 1950.

Since then, the company has grown into a business worth over $530 billion, with stores all around the globe. Yet, its headquarters remain in the small town of Bentonville.

2

Hormel Foods

Image: Hannes Johnson

From Skippy to Country Rock and even Spam, the Hormel Foods label carries a lot of successful brands. However, when the company was founded in 1891 in Austin, Minnesota, it began as a much more modest venture.

Even after over 130 years and a huge growth, the brand still remains in the charming little town of Austin and has no plans to relocate.

3

Kellogg's

Image: Yvens Banatte

In 1894, America’s breakfasts changed with the invention of the cornflake. W.K. Kellogg invented this wonder at the Battle Creek Sanitarium, a health resort run by his family. A few years later, in 1906, Kellogg founded his own company, the Battle Creek Toasted Corn Flake Company.

To this day, the massive company, which generates $13.5 billion in annual revenue, remains in Battle Creek, Michigan , a city of 51,000 residents.

4

Dick's Sporting Goods

Image: Artificial Photography

If you’ve ever thought that Dick's Sporting Goods sounds a bit like the name of a small-town shop, you are not wrong. The founder, Richard Stack, started his business in 1948 by opening a small fishing tackle store in Binghamton, New York.

By 1970, Stack had expanded the business to include gear for all kinds of sports and outdoor adventures. Today, the company, which is still family-run and operates out of Binghamton, generates $7.3 billion in annual revenue.

5

Kohler

Image: Oxana Melis

It’s not often that a town changes its name in favor of a company born there, but that’s exactly what happened in the tiny village of Riverside, which renamed itself Kohler. The company was founded in 1900 as a plumbing manufacturer and has since expanded its business into faucets, sinks, and toilets.

And, while the company has grown to be a multi-million-dollar enterprise, its headquarters remain in the picturesque village of, yes, Kohler, Wisconsin .

6

Progressive Corporation

Image: Jamie Street

Progressive Corporation is one of the largest car insurance companies in the U.S., also providing coverage for boats, motorcycles, and RVs. However, it started small in Mayfield Village, Ohio , in 1937. The company was founded by lawyers Jack Green and Joseph Lewis in their hometown, and it has remained headquartered there to this day.

7

CVS

Image: Tbel Abuseridze

This ubiquitous pharmacy chain opened its first store in 1963, and just seven years later, it had expanded to 100 locations. Today, CVS operates 10,000 stores nationwide while maintaining its small-town identity, thanks in large part to its headquarters in Woonsocket, Rhode Island .

8

Caterpillar

Image: Sindy Süßengut

A brand known for its ruggedness, Caterpillar Inc. makes tractors, construction, and mining equipment, and even clothing. The company is ranked in the Forbes list as one of the most valuable brands in the world, with over $51 billion in revenue. Despite its global success, Caterpillar still maintains its headquarters in the small town of Deerfield, Illinois .

9

The Hershey Company

Image: Janne Simoes

It makes sense that The Hershey Company, probably the biggest chocolate brand in the world, is headquartered in Hershey, Pennsylvania . The company produced its first product, Hershey’s Cocoa, in 1894 and has continued to grow and innovate ever since, all the while remaining in the small town that saw its birth.

10

Sonoco

Image: Kelly Sikkema

This packaging company produced its first product, a cone-shaped paper yarn carrier, over 120 years ago in Hartsville, South Carolina . These days, Sonoco is the world's largest producer of paperboard containers.

Despite its growth, the company has remained loyal to its roots, and its headquarters are still based in Hartsville.

1

Mississippi River

Image: Justin Wilkens

Beloved by blues musicians and immortalized by Mark Twain, the Mississippi has been central to exploration, trade, and American identity. The name comes from the Ojibwe/Anishinaabe word misi‑ziibi, meaning "Great River" or "Father of Waters."

Flowing some 2,320 miles, its watershed drains roughly 41% of the continental U.S., and its vast system remains critical for both commerce and agriculture.

2

Missouri River

Image: Jayden Herr

The name of the Missouri River comes from the Algonquian term ouemessourita, meaning "people with dugout canoes."

A crucial highway for early explorers like Lewis and Clark, as well as later settlers, this 2,300-mile-long river was once home to Native tribes such as the Missouria. Today, it remains a vital part of regional agriculture and river transport.

3

Hudson River

Image: Harry Gillen

Originally called Muh-he-kun-ne-tuk ("waters that are never still") by the Mohicans, the river was later renamed after Henry Hudson, who explored it in 1609 for the Dutch East India Company.

The Hudson Valley later grew into both an economic and cultural hub, inspiring the Hudson River School of painters and playing a strategic role during the American Revolution.

4

Colorado River

Image: Mike Newbry

The name Colorado comes from Spanish, meaning "reddish," a reference to the red silt once carried by the river. Before 1921, its upper course was known as the Grand River, until Congress renamed it to reflect the state of Colorado.

Over millions of years, the Colorado River carved the Grand Canyon, one of the world’s most dramatic natural landscapes. Today, it supports irrigation across seven U.S. states and northern Mexico and generates hydroelectric power through major dams such as Hoover Dam and Glen Canyon Dam.

5

Rio Grande

Image: Sara Cottle

The name Rio Grande means "Big River" in Spanish. Serving as the border between the U.S. (Texas) and Mexico, it has defined geopolitical boundaries since the end of the Mexican-American War in 1848.

Historically, the Rio Grande supported Indigenous communities such as the Pueblo and Apache peoples, and later Spanish missions and settlements. Today, it serves as a lifeline for agriculture, cities, and wildlife habitats across the arid regions of Texas, New Mexico, and northern Mexico along its 1,896-mile course.

6

Ohio River

Image: Joshua Canter

"Ohio" comes from the Seneca word ohi:yo’ , meaning "good river" or "large creek." Formed by the confluence of the Allegheny and Monongahela Rivers at Pittsburgh, it flows for about 981 miles through six states before joining the Mississippi River.

In early America, the Ohio was a key route for westward expansion and trade. Settlements along its banks grew into important commercial and industrial centers, including cities like Cincinnati, Louisville, and Pittsburgh, and its fertile floodplains supported agriculture that fueled the growing nation.

7

Columbia River

Image: Stephen Walker

The Columbia River was named after the Columbia Rediviva , the ship captained by Robert Gray , which itself was named in honor of Christopher Columbus. For thousands of years, the river served as a vital trade network for numerous Native American tribes, and later became central to the North American fur trade.

Its fertile valleys supported settlements and agricultural development throughout the Pacific Northwest. Today, the Columbia is a major source of hydroelectric power, with major dams such as Grand Coulee and Bonneville supplying electricity to millions of people.

8

Potomac River

Image: Sara Cottle

The name "Potomac" comes from a Native Algonquian word, likely Patawomeck (probably Piscataway), meaning "river of swans." The river flows past Washington, D.C., and George Washington’s Mount Vernon estate overlooks it.

During the colonial era and the Civil War, it was a crucial transport route, and its watershed continues to hold historical, cultural, and political significance today.

9

Delaware River

Image: Clay Banks

Named after Lord De La Warr (Thomas West), an English nobleman and colonial governor, the Delaware River is best known for George Washington’s daring 1776 crossing, which surprised Hessian troops in Trenton and provided a crucial morale boost for the Continental Army during the Revolutionary War.

Over the years, the river has remained vital for trade and industry, shaping the mid-Atlantic economy and supporting major ports in New Jersey, Pennsylvania, and Delaware.

10

Susquehanna River

Image: Jennifer Wick

The name "Susquehanna" likely comes from the Lenape word siskëwahane, meaning "Muddy River" (though other translations, such as "Oyster River," have been proposed). One of the oldest river systems in North America, the Susquehanna stretches about 444 miles from New York through Pennsylvania to the Chesapeake Bay in Maryland.

It supported Indigenous communities such as the Susquehannock, and early colonial settlements relied on it for transport, fishing, and trade. Its fertile valley later powered mills, contributed to the region’s coal and lumber industries, and played a key role in shaping the development of the Mid-Atlantic.

1

Rabies

Image: Samuell Morgenstern

Rabies-infected people and animals cannot swallow water. This is why rabid dogs drool at the mouth, because they are unable to swallow.

In the ancient world, a "cure" for rabies involved forcibly submerging people in bodies of water to force the liquid intake . Quite often, the consequence, as you might have guessed, was death by drowning.

2

Bloodletting

Image: David Trinks

In the days when barbers were also designated surgeons, bloodletting was a common cure for multiple conditions. This gruesome technique was performed not just using surgical tools but also by using leeches , which were directly applied on the human body , to suck blood out of the wretched individuals who required treatment.

3

Madstones

Image: Atul Vinayak

Folk remedies were common in a time when seeking professional medical help was a luxury for most people. Popular in mid-19th-century America, madstones were big hairballs extracted from the guts of goats and deer .

These objects were believed to possess medicinal properties, such as curing rabies and serving as an antidote to various poisons.

4

Chloroform

Image: Carlos Felipe Ramírez Mesa

Many substances that we now recognize as poisonous were once believed to be beneficial to health. During the 19th century, chloroform was commonly used as an anesthetic in surgeries .

However, later studies revealed that long-term exposure to chloroform could cause liver and kidney damage, respiratory depression, and may even increase the risk of cancer.

5

Arsenic

Image: Denise Chan

Another poisonous substance once thought to be beneficial was arsenic, which was used to treat malaria, syphilis, and other ailments during the 19th and early 20th centuries.

However, it was later discovered that arsenic exposure could lead to poisoning, causing severe health complications and even death.

6

Mercury

Image: Benjamin Hibbert-Hingston

Similar to chloroform and arsenic, mercury was once thought to be beneficial to the human body. However, as scientific understanding advanced, its harmful effects became widely known .

Today, we know that mercury is highly toxic and can cause severe damage to the kidneys and nervous system.

7

Urine

Image: Fotografía de Alimentos

Drinking urine for medicinal purposes was common in ancient Egypt, Greece, and Rome, where it was believed to have therapeutic benefits and was used as a remedy for various health conditions, including kidney and liver problems .

8

Trepanning

Image: Mathew Schwartz

Trepanning, a common medical practice in ancient civilizations, involved drilling a hole in the skull to relieve pressure or treat a variety of medical ailments such as headaches, seizures, and mental disorders .

However, due to the lack of modern anesthesia and surgical tools, the procedure was extremely dangerous and carried significant risks.

9

Cupping

Image: Katherine Hanlon

Creating a vacuum on the skin using heated glass cups was a popular therapy for various conditions, including pain, inflammation, respiratory problems, and digestive disorders . While not a particularly harmful technique, aside from the markings left on the skin, its benefits have not been scientifically proven.

10

Mummy powder

Image: Narciso Arellano

In medieval times, it was commonly believed that "mummy powder" possessed healing properties. This substance was made from ground mummies obtained from Egypt and was thought to be particularly effective in treating wounds, headaches, and digestive issues .

11

Nightshade

Image: Georg Eiermann

Nightshade is a poisonous plant with soothing properties, which was used as a pain reliever as it can induce a state of calm in the user.

However, this plant is also highly toxic and can cause hallucinations, delirium, and even death if consumed in large quantities.

12

Tobacco

Image: Juano colombo

It might be hard to believe today, but back in the 1600s, schoolchildren were encouraged to smoke cigarettes , which were then thought to be disinfectants.

Cigarettes were also believed to be beneficial for both the lungs and the mind. Thankfully, we now know better.